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Description

Quantitatively, haemoglobin and haemoglobin-haptoglobin complexes are likely to be the most significant extracellular sources of haem in vivo (Seale et al., 2006)

87 , e0278520 (2021)

Dis.,147:529-534 (1993)

[PubMed: 4370423] 519

Case studies demonstrating successful resolution of reactive metabolite liabilities are abundant in the medicinal chemistry literature and often involve the following strategies: (a) removal of the functional group susceptible to bioactivation, (b) modulation of electronic character (e.g