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In response to pathological lysosomal pH elevation in neurons of AD brain, a uniquely extreme autophagic stress 131 develops in the neuronal soma 131 , characterized by massive accumulation of inadequately acidified autolysosomes unable to degrade substrates, including APP-CTF and amyloid-, leading to intracellular formation of amyloid- 131 (Figs
Li KY, Tong WH, Hughes RM, Rouault TA (2006) Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly
J Thorac Cardiovasc Surg
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