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More studies are needed to determine which nutrients should be used in nutrition-based interventions (which exact nutrients/combinations/diets, dosages) and considering that vulnerability varies across the lifespan and between individuals, the optimal time window of opportunity (i.e

It can also be absorbed with food

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For example, Bezafibrate activates PPARs and enhances the transcription of genes associated with mitochondrial biogenesis [171]

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Image created by author with BioRender.com The classical presentation of GHI, termed Laron syndrome (OMIM #262500), comprises severe short stature, delayed bone age, delayed tooth eruption, delayed puberty and distinctive facial features including frontal bossing, mid-facial hypoplasia and occasionally blue sclera