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(February 2022)

Acknowledgments We thank Dina Harleaux, Lynne Scott, Varsha Patel, and the nursing staff of the Baylor General Clinical Research Center for excellent care of subjects and meticulous attention to protocol

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Sullivan et al., 2000) of phosphorylative cascade, MAPKs ( The outstanding progress accomplished in the last years allows to assert that, even though the pathways implicated in the induction/execution of apoptosis have remained largely unaltered, many new redox-dependent processes have been added and we suggest the reading of several reviews on this subject ( From the first evidence regarding the involvement of GSH in apoptosis, up to date many improvements have been made, and growing results, which attempted to dissect the mechanisms linking GSH to cellular redox-dependent processes, were added

In an aging brain, oxidative stress is a major contributing factor to chronic inflammation, leading to cognitive impairment, memory issues, or more serious manifestations