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The IVD is characterized by an avascular, nutrient-poor, hypoxic, acidic, hyperosmolar, and mechanically stressed environment (Wang et al., 2015)

Apart from its intrinsic function in tumor and immune cells, cGAS-STING can signal intercellularly by cGAMP spreading to neighboring cells via gap junctions (134, 216, 217)

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doi: 10.1111/j.1742-4658.2008.06542.x

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Folate content in boiled (heated to boiling temperature and then simmered for 2 h) soaked peas and chickpeas decreased by 55% and 47%, and that in pressure-cooked (for 20 min) ones by 49% and 38%, resp., compared to raw legumes