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Overview of Senolytics Senolytics are a class of therapeutic agents specifically designed to eliminate senescent cells, which are cells that have entered an irreversible condition of cell cycle arrest while remaining metabolically active.36 Numerous stressors, such as telomere attrition, oxidative stress, DNA damage, and oncogene activation, induce cellular senescence.1 Initially, senescence safeguards against cancer by inhibiting the proliferation of damaged cells

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Clinical studies using VitC in combination with targeted therapy Three non-randomized clinical studies administered targeted agents on top of chemotherapy and high-dose IVC [151, 153, 155]

[DOI] [PubMed] [Google Scholar] Suppadungsuk S, Phitakwatchara W, Reungwetwattana T, Pathumarak A, Phakdeekitcharoen B, Kitiyakara C, Srisuwarn P, Davenport A, Nongnuch A (2022) Preloading magnesium attenuates cisplatin-associated nephrotoxicity: pilot randomized controlled trial (PRAGMATIC study)