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P.CularD.MileticA.et al (2020)

It is currently indicated for use in adults with obesity (with a BMI of 30 kg/m2 or greater) or overweight adults (with a BMI of 27 kg/m2 or greater) who also have weight-related medical problems such as type 2 diabetes, high blood pressure, obstructive sleep apnea, or cardiovascular disease

Bipolar disorder, manic, with psychotic features This 33-year-old woman presents with a two-month history of grandiose and paranoid delusions, auditory hallucinations, pressured speech, loose associations, and a decreased need for sleep

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The threshold increase is precautionary

Future research should prioritise long-term outcomes in high-risk groups, comparisons of physiological versus pharmacological dosages in healthy subjects, cost-effectiveness analyses, and adherence monitoring to inform clinical guidelines for the management and prevention of B12 deficiency