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MetE protein formulated with AS01 adjuvant generated a robust Th1-biased CD4+ T cell response, characterized by antigen-specific IFN-, TNF-, and IL-2 production ( Figures 6A, B ), alongside a broad humoral response with statistically significantly elevated IgG1, IgG2a, IgG2b, and IgG2c levels compared to nave group ( Figure 6C )

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This is because cells need a certain level of stiffness to generate the traction forces required for movement, while excessive stiffness makes it difficult to remodel the matrix or detach the trailing edge of the cell [15]