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Daston, Lorraine, and Peter Galison

Color: Blue

Exposure to CSE from 3R4F, NF and ultralow nicotine cigarettes negatively impacts ZO-1 and occludin expression/distribution as well as BBB integrity Immunofluorescence analysis of BBB endothelial confluent monolayers revealed a significant loss of ZO-1 at cell-cell junctions following exposure to CSE from 3R4F, Ultralow and NF cigarettes and to a lesser extent in 1R5F treated cultures (compared to controls, Figure 4A)

doi:10.1111/add.15386 50

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128 In 2015, 16.7 percent of adult males and 13.6 percent of adult females smoked cigarettes