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A Role for Uric Acid in the Progression of Renal Disease

This makes it a potentially safer option for individuals concerned about insulin sensitivity or diabetes risk

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To address this gap, future studies should integrate cryo-electron microscopy and molecular dynamics simulation to elucidate the binding sites and conformational changes of CAT with TRPV1/SLC2A1, as well as the molecular switch mechanism governing the synergistic regulation of the dual pathways