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Versus Steroids: Corticosteroids suppress inflammation but weaken tissue over time

Wang H, Chen Y, Wang L, et al

Mice had free access to food and water and were housed in a room with a 12 h light/12 h dark cycle (07:0019:00 h), ambient temperature at 1923 C and humidity at 4070%

Biomechanical alterations of the ECM, including increased ECM rigidity or forces of varying strengths and dynamic characteristics, modulate form and the functions of cells with an inevitable impact on the cellular behavior and therefore drive distinct fibrotic signaling pathways (Orr et al., 2006

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Bacteroides , and those living in a region with high helminth infections have a higher abundance of Faecalibacterium and Prevotella