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Furthermore, treatment of cells with 22(R)-diol and pregnenolone and ensuing oxidative stress resulted in decreased mRNA levels of StAR and CYP11A1 and increased mRNA levels of antioxidant enzymes SOD1, SOD2 and CAT

Notably, three differentially expressed genes (HMGB1, CP, TF), at the single-cell level, encode secreted proteins which may impact the susceptibility of dopaminergic neurons in the SN of PD patients to ferroptosis

Despite the presence of antioxidant agents within the lens (such as vitamins and antioxidant enzymes), OS is widely recognized as a major contributor to cataract development, alongside other environmental and endogenous factors [205,206,210,211]

Sarhan, J

These pathways are important in the pentose phosphate pathway that involves transaldolase, which is encoded by the TALDO1 gene (659) and has been linked to Parkinsons disease (660)