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Research in the Journal of Clinical and Cosmetic Dermatology suggested that doses up to 2000 mg daily may be safe and potentially more effective for achieving rapid skin-lightening results

The ENS affects bone by secretion of neuropeptides like substance P, which may enhance bone formation (274, 275), and secretion of molecules like vasoactive intestinal peptide, which may suppress osteoclast activity and bone resorption (276)