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NRF2 is an essential upstream regulator that controls the expression of antioxidant genes, it controls the activities of GPX4 and the System Xc , which are vital for glucose metabolism [58]

From this study, the authors suggested the cutoff value for combined SOD and GPx activity

Conversely, GOF mutant alleles can be engineered to confer novel or enhanced functions to the gene product, leading to altered protein properties, such as increased activity or modified substrate specificity