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Bag-Ozbek A, Hui-Yuen JS (2021) Emerging B cell therapies in systemic lupus erythematosus

The effect of Fer-1 was verified with experimentally administered ventricular Fer-1 in experiments with rats, where it was found to inhibit erastin-induced accumulation of ROS in the cytoplasm and lipids, resulting in a decrease in ROS and lower levels of ferroptosis, demonstrating that Fer-1 could appreciably slow down the onset of ferroptosis in the brain (171)