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[DOI] [PubMed] [Google Scholar] 34.Anand P., Kunnumakkara A.B., Newman R.A., Aggarwal B.B

The applied ASO doses can be directly correlated with knockdown efficiencies and cellular toxicity

The control variant showed the lowest concentration, while BF_V4 had the highest, suggesting that oak chips may promote octanoic acid formation

These alterations increase the NADH/NAD+ ratio, which inhibits Complex I activity and promotes electron leakage to oxygen, generating additional superoxide radicals and intensifying oxidative injury (130)

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As long as its localized and not a widespread rash, its generally considered a minor, temporary side effect