However, the story is much more complex and interesting and the last decade has witnessed a seismic shift in our level of knowledge about the pharmacological mechanisms and clinical benefits that are offered by the phytocannabinoids present in Cannabis sativa
ISSN 0364-3190, 1573-6903
10.1089/acm.2010.0716 69
Cao D, Shen K, Li Z, Xu Y, Wu D
Access this chapter Subscribe and save Buy Now Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others Abbreviations BMI: Body mass index CAT: Catalase COPD: Chronic obstructive pulmonary disease Cu-Zn-SOD: Copper, zinc superoxide dismutase CVD: Cardiovascular diseases DM2: Type 2 diabetes mellitus DNA: Deoxyribonucleic acid DNPH: 2,4-dinitrophenylhydrazine Fe-SOD: Iron superoxide dismutase FMOC: 9-fluorenylmethoxycarbonyl hydrazine GPx: Glutathione peroxidase GPx-1: Glutathione peroxidase 1 GPx-2: Glutathione peroxidase 2 GPx-3: Glutathione peroxidase 3 GPx-4: Glutathione peroxidase 4 GR: Glutathione reductase GSH: Reduced glutathione GSSH: Oxidized glutathione H 2 O 2 : Hydrogen peroxide Hb: Hemoglobin HPLC: High-performance liquid chromatography KCN: Potassium cyanide LDL: Low-density lipoproteins LP: Lipid peroxidation M1dG: 3-(2-deoxy--d-erythro-pentafuranosyl) pyrimido[1,2-]purin-10(3H)-one deoxyguanosine MDA: Malondialdehyde Mn-SOD: Manganese superoxide dismutase NADPH: Nicotinamide adenine dinucleotide phosphate NU: Nitrite units O 2 -: Superoxide anion PUFA: Polyunsaturated fatty acids ROS: Reactive oxygen species SNP: Single-nucleotide polymorphism SOD: Superoxide dismutase SOD1: Superoxide dismutase 1 SOD2: Superoxide dismutase 2 SOD3: Superoxide dismutase 3 TBA: Thiobarbituric acid TBARS: Thiobarbituric acid reactive substances TXA2: Thromboxane A2 U/g Hb: Units per gram of hemoglobin References Aebi H
Overall, although current evidence indicates that RNA-LNPs can be relatively safe and efficacious, especially in nonpregnant adults, more comprehensive preclinical and clinical investigations are required
