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doi: 10.1128/spectrum.02774-24

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Elevated levels of neutrophils with neutrophil extracellular traps (NETs and NETosis) and associated immune-thrombosis are prominent features of COVID-19 pathology 215,216

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Thus, this could necessitate careful interpretation of its biological effect in vivo and suggests importance of targeting and assessing other more specific downstream mediators, i.e., RIPK3 and MLKL for suppressing necroptosis