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Small-molecule inhibitors of the protein methyltransferase SET7/9 identified in a high-throughput screen

[DOI] [PubMed] [Google Scholar] 113.Gurney J.G., Bass J.K., Onar-Thomas A., Huang J., Chintagumpala M., Bouffet E., Hassall T., Gururangan S., Heath J.A., Kellie S., Cohn R., Fisher M.J., Panandiker A.P., Merchant T.E., Srinivasan A., Wetmore C., Qaddoumi I., Stewart C.F., Armstrong G.T., Broniscer A., Gajjar A

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Under physiological conditions, immature neurons exhibit high expression of NKCC1 and low expression of KCC2, resulting in elevated intracellular Cl - levels

Higher levels of these inflammatory cytokines have been found in CSF and serum of patients with ALS and correlate negatively with survival, specifically TNF-alpha, interleukin-10 and interleukin-1 beta [236]

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