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The micelle provides good opportunities for drug co-delivery and controlled drug release, while reducing drug leakage during circulation and avoiding toxic effects, without requiring complicated custom modifications or alterations, due to its maneuverability of drug loading and redox-sensitive characteristics

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Additionally, the role of population heterogeneity remains poorly understood: patients with distinct types of sleep disorders (including insomnia and sleep apnea syndrome) exhibit differential responses to magnesium-based interventions

For example, introducing the eNOS gene enhance the ability of endothelial cells to synthesize NO, improve endothelial-mediated vasodilation function, and reduce the production of ROS in renal blood vessels (Figure 3