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Third, tool sprawl is the silent killer of operational efficiency, and recurring-care models like weight loss feel it acutely because the refill-and-retention loop touches so many systems

Considering the inflammatory framework of PD, IL-13 appears to act as a susceptibility-modifying factor rather than as a classical inflammatory mediator

Damaged airway epithelial cells release mtDNA and N-formyl peptides that activate STING and NF-B pathways in immune cells, amplifying inflammation [141]

Similarly, astrocytes shift toward the neurotoxic A1 phenotype with downregulation of A2 markers

Nelson DB, Rice DC , Mitchell KG, Tsao AS, Vaporciyan AA, Antonoff MB, Hofstetter WL, Walsh GL, Swisher SG, Roth JA, Gomez DR, Mehran RJ, Sepesi B

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