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Radiotherapy inhibits tumor growth by generally inducing tumor cell apoptosis, senescence, autophagy, necrosis, or mitotic catastrophe through inflicting extensive DNA damages (Valenciano et al., 2012

10.1016/j.tibs.2006.11.003 159 KocatrkB.LeeY.NosakaN.AbeM.MartinonD.LaneM

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Our findings are in line with other reports showing a decrease in Sirt6 protein expression in transgenic mice (5XFAD) 133 as well as decreased gene and protein expression in AD patients 133,134