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Description

2017;1:CD010369

Pharmaceuticals 13 , 427 (2020)

Cells 12 (14), 1820

AMPK activation by metformin depends on liver kinase B1 (LKB1) and is essential for suppressing hepatic gluconeogenesis (Shaw et al., 2005)

It also reduced hepatic levels of a component of bile acid named taurochenodeoxycholic acid (TCDCA), which typically induces mitochondrial permeability transitions and caspase-11-dependent pyroptosis