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Int J Mol Sci (2020) 21:3743

Ann Palliat Med

In addition, predictive biomarkers could be identified for disease states such as obesity, IBD and cancer that are characterized by alterations in the GI tract microbiota 45

Even if cysteine S -conjugate -lyase is responsible for the synthesis of the highly reactive and cytotoxic thiol version of cisplatin ( Figure 1 ), the activation of cisplatin into a nephrotoxin relies on the three previous steps of the classical mercapturic acid pathway involving GSTs (GSH conjugation), GT (production of CisPt-cys-glu) and dipeptidase (production of CisPt-cys