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Molecular characterization of three estrogen receptor forms in zebrafish: binding characteristics, transactivation properties, and tissue distributions

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Biomarker studies: establishing senescent cell burden diagnostic (e.g., imaging, blood markers) to monitor effect and guide dosing

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When retatrutide binds to GLP-1 receptors, it stimulates insulin release from the pancreas, reduces glucagon secretion, delays gastric emptying, and suppresses appetite through direct signaling to the brain