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Computational design of MmpL3 inhibitors for tuberculosis therapy

Drugs A and B were examined as single agents, and the MIC for each of them was recorded

Abstract Mast cells are localized throughout the body and mediate allergic, immune, and inflammatory reactions

In this work, we explored the biological effect of nano-SARs, by developing a microenvironment-responsive in vivo self-assembled peptide-ferriporphyrin conjugates ( Gi-F-CAA ) for improving tumor penetration, accumulation and binding affinity with GPX4, ultimately synergistically enhancing ferroptosis-based anticancer activity

This finding is devastating

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