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If a skin biopsy is performed because the lesion is changing or looks irregular, a melanotic lip macula shows the following characteristics in dermatopathology: Increased melanin at melanocytes and keratinocytes of the basal cap Melanophages at dermal papillae, which indicates pigmentary incontinence Mild acanthosis without lengthening the challenge ridges Nuclear atypia is absent and the melanocyte The count is normal

Microscopically, there is increased pigment in the basal and parabasal cells of an otherwise normal stratified squamous epithelium (the layered surface lining of the mouth)

J Cell Sci (2009) 122(Pt7):102534

The radiation dose required for optimal disease control remains uncertain

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Sigma-Aldrich, Shanghai, China) solution at a dose of 0.1 g/kg body weight by oral gavage