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This activation then triggers the transcription of the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) gene, causing podocyte pyroptosis and contributing to the development of DKD[36]

Furthermore, ROS signaling could be mediated by cytokines, whose participation in cellular pathways is modulated by redox status [3546, 169177]

Alternative Medicine Review, 16 (4), 355364

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Specifically, an initial reduction followed by a substantial increase in beta-endorphin levels was observed, a pattern that suggests DSIPs impact on the opioidergic system, potentially playing a role in stress alleviation or adaptation processes