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[DOI] [PubMed] [Google Scholar] 38.Hackl H, Burkard TR, Sturn A, Rubio R, Schleiffer A, Tian S, Quackenbush J, Eisenhaber F, Trajanoski Z

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This results in HIF-1 translocation into the nucleus, where in a complex with HIF-1 it activates transcription via binding to hypoxia responsive elements (HRE) in the promoters of corresponding genes (Kim et al., 2021)

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CYP2E1 activation from heavy drinking diverts hepatic resources away from cannabinoid metabolism, while acetaldehyde accumulation adds toxic burden