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CoQ10 supplementation, when added to pregabalin, significantly reduced pain and mitochondrial oxidative stress in FM patients, with improved anxiety and brain activity profiles in a small RCT ( Oxygen-ozone (OO) therapy, an intervention that activates NRF2, increases SOD, catalase, and HO-1, while suppressing pro-inflammatory cytokines (IL-6, TNF-, IL-1) ( , HO), protecting mitochondria, and enhancing ATP production ( Molecular hydrogen (H) is emerging as a potential therapy targeting oxidative stress, mitochondrial dysfunction, and inflammation

doi: 10.3390/jcm10153240

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Future research about glutathione could entail creating delivery systems that include using nanoparticles or liposomes to increase absorption and bioavailability