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Shaibani, A

a preferred humectant is shae butter

10.1016/j.biopha.2023.115895 38

and Smith, U.P

IL-1 ubiquitylation on lysine K133 promotes IL-1 turnover, and loss of IL-1 K133 ubiquitylation via the generation of Il1b K133R/K133R mice enhances i) pro-IL-1 protein levels, ii) the capacity of IL-1 to be activated following NLRP3 triggering, and iii) increases levels of precursor and activated IL-1 following LPS injection