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Nature medicine 31(3):901-908, 2025

Ziemann et al., 2015)

Cofactor-supplemented incubation experiments were performed to confirm their formation pathways because M3 and the O -methylated metabolites of M1 (M5 and M6) share the same nominal mass

Pyroptosis is caused by inflammasome-induced activation of caspase-1 which can subsequently cleave its substrates, such as pro-inflammatory cytokines and GSDMD which trigger inflammatory response and pyroptosis, respectively