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In investigating the neurological and cognitive functions of aged mice in a study focused on the auditory cortex, the effect of alleviating ferroptosis in the brain was achieved by treatment with DFO, suggesting that DFO may be used to treat auditory and cognitive impairment resulting from age-associated problems (169)

The integration of omics data (e.g., transcriptomic, proteomic and metabolomic) into the risk assessment of chemical mixtures has great potential to reveal combined effects at a mechanistic level, providing insights into modes of action or adverse outcome pathways

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405 nm and 488 nm are the excitation wavelengths used for confocal imaging

In addition to causing pleural mesothelioma, asbestos, a classic inorganic fiber, can translocate to the brain tissue, which is correlated with A deposition and reduced acetylcholine [225, 226], thereby contributing to AD pathology [227]

ROS are known to stabilize HIFs in the hypoxic milieu in the brain [33]