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Cell Tissue Res 270 , 475484 (1992)

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the engineered antibody may be composed of one or more CDRs that are, for example, 90%, 95%, 98%, 99% or 99.5% identical to one or more CDRs of the M25ADLF, M25ADLFEG, M25ADLFDS, M25FYIA, M25FYIAEG, M25FYIADS, M25, M25EG, M25DS, one or more residues of a CDR may be altered to modify binding to achieve a more favored on-rate of binding

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No significant downtime is required