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In patients with mild cognitive impairment (often a precursor to Alzheimers disease), prolonged melatonin supplementation reportedly slowed the progression of cognitive decline and improved sleep and mood, though larger trials are needed

Hu H, Lin A, Kong M, Yao X, Yin M, Xia H, et al

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Nano-Armed Limosilactobacillus reuteri for Enhanced Photo-Immunotherapy and Microbiota Tryptophan Metabolism against Colorectal Cancer

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Oxidative stress is a major driver of ferroptosis, with excessive MitoROS accumulation leading to lipid peroxidation and the exacerbation of IDD