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For example, catalpol attenuates depression-like behaviour in pathological hyperglycaemic states, and its antidepressant mechanism is attributed to the upregulation of PI3K/AKT/Nrf2/HO-1 signalling pathway by reversing the abnormal phosphorylation of PI3K and Akt, as well as the abnormal levels of Nrf2 protein, HO-1 and superoxide dismutase, glutathione peroxidase, glutathione transferase, and reducing glutathione (Zhao et al., 2012)

Nature 569 , 503508

This phenomenon might suggest why quercetin had a similar dynamic behavior as that of FAD when bound to the protein but didnt show quality behavior as compared to other two phytochemicals

Markello TC, Bernardini IM, Gahl WA (1993) Improved renal function in children with cystinosis treated with cysteamine

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XY: Writing original draft