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10.1002/oa.601 8 BallantyneR.CooperA.RajkovaaV

An early clinical trial in 13 patients with type 2 diabetes found that a single intravenous infusion of 1,000 mg of lipoic acid improved insulin-stimulated glucose disposal (i.e., insulin sensitivity) by 50% compared to a placebo infusion (57)

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The obtained list of activators includes various molecules, ranging from non-cellular compounds like drugs to intracellular metabolites produced within the cell

Nikseresht S, Khodagholi F, Ahmadiani A (2019) Protective effects of ex-527 on cerebral ischemia-reperfusion injury through necroptosis signaling pathway attenuation