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However, HDAC6 inhibitors are poorly soluble in water which restricts their bioavailability and BBB permeability

A recent study has shown that Yap is associated with the activation of ferroptosis, Yap can promote an iron environment in cancer cells through stimulating transcription of TEAF-based members of the Transferrin receptor (TFRC) and Acyl-CoA synthetase long chain family 4 (ACSL4) [129, 130]

The challenges in targeting KRAS stem from its biological characteristics, such as a smooth surface lacking deep binding pockets and its high-affinity GTP-binding activity, which made the development of small-molecule inhibitors particularly difficult

In addition to direct effects on hepatic lipid synthesis, LXR repression exerts pleiotropic effects to reduce dyslipidemia

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