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680,681,682 Small molecules targeting ferroptosis by regulating the ACSL4-LOX axis Lipid peroxidation is a hallmark of ferroptosis, and lipid-metabolizing enzymes such as ACSL4 and LOX contribute to ferroptosis

Cell viability assay Cells were seeded in 96-well plates at a density of 1.0 10 4 cells per well in 100 L of growth medium

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[34] This specific distribution enables the measurement of urinary GSTs to be used to quantify and localise renal tubular injury in transplantation, nephrotoxicity and ischaemic injury

In the GSH driven antioxidant actions of enzymes such as glutaredoxin, GSH is oxidized to glutathione-disulfide (GSSG)

its breakdown by GGT