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Amino acids are often celebrated as the essential building blocks of proteins, vital for our health and body functions

doi: 10.1016/j.fochms.2022.100119 48

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Hongisto, Vesa

Moreover, ferroptosis is associated with pathological accumulation of senescent fibroblasts in diabetic wounds, which impairs cell motility and proliferation

The high dependency of therapy-resistant mesenchymal cancer cells (with high ZEB1 expression) on the lipid peroxidase pathway governed by phospholipid glutathione peroxidase 4 ( GPX4 ) increases their vulnerability to ferroptosis via GPX4 inhibition or GSH depletion with erastin treatment [9]