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NKX21 overexpression enabled Ba/F3 cells to synthesise serine and glycine from glucose, presenting a 1.6-fold increased M + 3 serine and a 5-fold increased M + 2 glycine as compared to vector control cells (Fig

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10.1002/wsbm.1644 131 ZhouL.WanY.ChengQ.ShiB.ZhangL.ChenS

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For example, ex vivo pharmacologic or genetic reprogramming of CD8 + T cell lipid peroxidation prior to adoptive cellular therapy was able to enhance their effector function or longevity in vivo ( Figure 4 Current studies have provided new insights into the molecular mechanisms of lipid peroxidation in regulating immune cell function in TME