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Mitochondria, the powerhouses of the cell, are particularly vulnerable to damage from reactive oxygen species

B.NadkarniG.WangL.CaiW.et al (2016)

Similarly, ATMs in lean subjects are supported by fatty acid oxidation (FAO), glycolysis and glutaminolysis (anti-inflammatory macrophage), while ATMs in obese subjects depend more on glycolysis (pro-inflammatory macrophage) [9]

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316 , 317 This oxidative stress environment may further activate tau protein kinases (such as GSK-3) and accelerate the abnormal phosphorylation process of tau protein