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2.8 p53 The p53 gene was discovered in 1979, and studies have shown that p53 serves dual functions in ferroptosis regulation (79)

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doi: 10.3390/plants2040541 61 MatsuoY.NoviantiF.TakeharaM.FukuharaT.ArieT.KomatsuK

4.1 Iron chelators Iron chelator has the ability to become a stable complex through strong binding with iron ion, thus preventing too much free iron ion from participating in redox reaction in cells to produce ROS, initiate lipid peroxidation, cause cell oxidative damage and trigger ferroptosis