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At elevated concentrations (510 M), curcumin directly binds to the DNA-binding domain of the NF-B p65 subunit (Kd = 2.3 nM) and the adenosine triphosphate (ATP)pocket of IKK (G = 7.6 kcal/mol), exerting steric hindrance to impair their functions (Wang et al., 2018

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