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Most Addictive Substances Ranked Tobacco Nicotine Rutgers Addiction Research Center (RARC) Five Topmost Addictive Substances in the World Tobacco : Behind the Smoke (infographic) Most tobacco products, including e cigarettes, contain nicotine, a chemical that can harm the heart, brain and whole body. As with other addictive products, using a nicotine product builds tolerance, leading to more Smoking Information and Tips for Quitting
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