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Various phosphospecific antibodies were used in the IHC analysis to provide both qualitative and quantitative information of the signalling pathways in the tumours (Figure 4)

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Chronic exposure to these drugs depletes presynaptic monoamine stores, impairs long-term neuronal signaling, and induces neurodegeneration ( 4.2 Oxidative stress and mitochondrial dysfunction The excessive release of monoamines promotes ROS formation through the auto-oxidation of dopamine and norepinephrine

Taher, A