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This is especially concerning for vulnerable populations, such as older adults, who may face challenges in maintaining adequate zinc intake, as they may experience reduced appetite, changes in taste, dietary restrictions, poor dental status and age-related digestive issues that hinder nutrient absorptions [32,33,34,35]

Therefore, restoring the barrier function of BBB may serve as an effective approach to treat SAE

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( A ) Aligned sequences surrounding the NPEY motif in the juxtamembrane regions of the insulin and IGF1Rs in several species are shown, illustrating the constant leucine in the position in IR and phenylalanine in IGF1R

PLoS ONE 10 , e0134087 (2015)

Allow the vial to reach room temperature for 15-30 minutes before opening to prevent condensation