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A., Kanaki, T., Slominski, A

Direct application of ROS over a relevant time course to tissues at concentrations found in vivo should reproduce damage similar to that observed in the diseased tissue

In fact the ELF concentration of GSH is 140 times that of blood serum concentrations with a redox ratio of greater than 9:1

Zhang Y, Li M, Gao X et al (2019) Nanotechnology in cancer diagnosis: Progress, challenges and opportunities

ROS and RNS production following IRI damage results from the complex interplay of multiple cellular pathways

Recent research determined that aryl hydrocarbon receptor (AhR) activation after alcohol intake in the liver, which is mediated by Protein Phosphatase 2 Regulatory Subunit-Bdelta (Ppp2r2d) to promote AMPK dephosphorylation, leading to autophagy inhibition and mitochondrial dysfunction (Kim et al., 2022)