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The cystine taken into the cell is reduced to cysteine, part of which participates in intracellular GSH synthesis and the other part flows out of the cell to be converted to cystine and re-involved in the System Xc- (Liu N

Funding This work was supported by a grant for Research on the Molecular Mechanism and Targeted Therapeutic Strategies of Sciatica (No

Oxidative modifications may impair the expression or activity of sarcoplasmic reticulum Ca 2 -ATPase (SERCA2a), leading to defective Ca 2 reuptake during diastole, sustained cytosolic Ca 2 elevation further causes diastolic dysfunction and delayed relaxation [44]

Even so, it is also possible to get it from food sources

Gao Z, Xu Z, Hung MS, Lin YC, Wang T, Gong M, Zhi X, Jablon DM, You L: Promoter demethylation of WIF-1 by epigallocatechin-3-gallate in lung cancer cells