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Haanen J, Ernstoff MS, Wang Y, Menzies AM, Puzanov I, Grivas P, et al

FIGURE 4 3.4 Nitazoxanide reduced apoptosis in rats with MTX-hepatotoxicity MTX significantly induced hepatic apoptosis as demonstrated by increased proapoptotic markers, Bax level, and caspase-3 activity (Figures 5A, D) while reduced antiapoptotic Bcl-2 level (Figure 5B) and increased Bax/Bcl-2 ratio (Figure 5C) compared to CTRL group

Mok A, Rhead B, Holingue C, et al

Short chains of fewer than 50 amino acids penetrate cell membranes and tissue barriers more readily than larger protein complexes, enabling target specific receptor engagement with greater efficiency

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de la Chapelle, et al